Related Experiment Video
Updated: Jul 2, 2025
04:40
Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
Published on: January 5, 2024
2.3K
Primary prevention of venous thromboembolism for cancer patients in randomized controlled trials: a bibliographical
Lucy Zhao1, Jayhan Kherani1, Pei Ye Li2
1Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Research and Practice in Thrombosis and Haemostasis
|February 26, 2024
Summary
Commercial sponsorship did not bias randomized controlled trials (RCTs) on venous thromboembolism (VTE) prophylaxis in cancer patients. Few differences were found between commercially and noncommercially sponsored studies, suggesting reliable evidence.
Area of Science:
- Oncology
- Clinical Trials
- Hematology
Background:
- Most randomized controlled trials (RCTs) for venous thromboembolism (VTE) prophylaxis in cancer patients are commercially funded.
- Commercial sponsorship aids trial feasibility but raises concerns about potential bias.
Purpose of the Study:
- To compare trial characteristics between commercially and noncommercially sponsored RCTs investigating VTE prophylaxis in cancer patients.
- To assess potential bias in commercially sponsored VTE prophylaxis trials in oncology.
Main Methods:
- Systematic search of Medline, Embase, and Cochrane Central Register for relevant RCTs.
- Independent reviewer screening and data extraction.
- Statistical comparison of trial characteristics, including outcomes reporting, spin, and protocol adherence.
Main Results:
- Of 54 analyzed RCTs, 63% were commercially sponsored.
- Commercial sponsorship was not linked to biased outcomes reporting, spin, or discrepancies.
- Commercially sponsored trials showed more intention-to-treat analyses; noncommercially sponsored trials favored retrospective registration and composite outcomes.
Conclusions:
- Limited differences exist between commercially and noncommercially sponsored VTE prophylaxis RCTs in cancer.
- Evidence from commercially sponsored trials in this area is unlikely to be biased by sponsorship.
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