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Cholesterol metabolism: physiological regulation and diseases

Jiarui Guo1, Silong Chen1, Ying Zhang1,2

  • 1Eye Center of the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang Province China.

Medcomm
|February 26, 2024
PubMed

Insights

Disruptions in cholesterol metabolism impact cardiovascular disease and other ailments. This review explores cholesterol

Area of Science:

  • Biochemistry
  • Cellular Biology
  • Metabolic Disorders

Background:

  • Cholesterol homeostasis is vital for cellular and systemic health.
  • Disordered cholesterol metabolism is linked to cardiovascular disease (CVD) and other systemic conditions.
  • The complex regulation of cholesterol involves synthesis, intake, efflux, and storage.

Purpose of the Study:

  • To review the human cholesterol metabolic process, emphasizing reverse cholesterol transport (RCT).
  • To discuss the impact of abnormal cholesterol metabolism on various diseases.
  • To identify potential therapeutic targets for cholesterol-related diseases.

Main Methods:

  • Literature review of cholesterol metabolism and its role in disease pathogenesis.
  • Analysis of the impact of dysregulated cholesterol on CVD, tumors, neurological, and immune diseases.
  • Focus on cholesterol's role in eye diseases.

Main Results:

  • Abnormal cholesterol metabolism is implicated in a wide range of systemic diseases.
  • The exact mechanisms linking cholesterol metabolism to disease pathogenesis require further elucidation.
  • Reverse cholesterol transport (RCT) plays a critical role in maintaining cholesterol balance.

Conclusions:

  • Understanding cholesterol metabolism offers new insights into disease pathogenesis.
  • Targeting cholesterol metabolism pathways presents potential therapeutic strategies for multiple diseases.
  • Further research is needed to clarify the intricate relationship between cholesterol and disease.

Keywords:
cholesterolcholesterol metabolismdiseaseseffluxregulationreverse cholesterol transport

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