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Updated: Jul 2, 2025
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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
Published on: May 6, 2022
4.5K
Epigenetic modifications in obesity-associated diseases.
Yiqian Long1,2, Chao Mao2,3, Shuang Liu1,2,4
1Department of Pathology, Xiangya Hospital Central South University Changsha Hunan China.
Medcomm
|February 26, 2024
Summary
Obesity
Area of Science:
- Metabolic and Cancer Research
- Epigenetics and Chronic Disease
Background:
- Global obesity epidemic increases risk for cardiometabolic diseases and cancer.
- Obesity causes metabolic dysfunction, inflammation, and cellular damage, promoting cancer.
- Behavioral factors like diet and exercise influence obesity via epigenetic changes.
Purpose of the Study:
- To review the role of epigenetic regulation in obesity-related diseases.
- To explore how epigenetic modifications impact cancer, type 2 diabetes, and cardiovascular disease.
- To establish a theoretical foundation for preventing and treating obesity-associated conditions.
Main Methods:
- Comprehensive literature review on epigenetics and obesity-related diseases.
- Analysis of studies linking epigenetic alterations to metabolic dysfunction and cancer.
- Synthesis of evidence on the reversibility of epigenetic changes.
Main Results:
- Epigenetic modifications are involved in the early stages of obesity and its complications.
- Some epigenetic changes are reversible, offering therapeutic targets.
- Epigenetic regulation influences the development of obesity-associated cancers, type 2 diabetes, and cardiovascular diseases.
Conclusions:
- Epigenetic modifications are crucial in obesity's initiation and progression.
- Targeting epigenetic mechanisms offers potential for treating obesity-related diseases.
- Understanding epigenetic dynamics aids in prevention, diagnosis, and treatment strategies.
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