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Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
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Low thyroid function is associated with metabolic dysfunction-associated steatotic liver disease.

Shuo Wang1, Ding Xia1,2, Hong Fan1

  • 1Department of Epidemiology, School of Public Health Fudan University Shanghai China.

JGH Open : an Open Access Journal of Gastroenterology and Hepatology
|February 26, 2024
PubMed
Summary

Metabolic dysfunction-associated steatotic liver disease (MASLD) is linked to low thyroid function. This association is independent, highlighting thyroid health

Keywords:
low thyroid functionmetabolic dysfunction‐associated steatotic liver diseasethyroid stimulating hormone

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Area of Science:

  • Endocrinology
  • Hepatology
  • Metabolic Disorders

Background:

  • Metabolic dysfunction-associated steatotic liver disease (MASLD) is a new term emphasizing cardiometabolic dysfunction's role.
  • MASLD replaces non-alcoholic fatty liver disease to better reflect metabolic links.

Purpose of the Study:

  • To investigate the association between low thyroid function and MASLD.
  • To examine this relationship within the updated MASLD context.

Main Methods:

  • A retrospective cohort study included 2901 participants from 2016-2021.
  • Participants were categorized by thyroid stimulating hormone (TSH) levels into strict-normal and low thyroid function groups.
  • Cox regression models analyzed hazard ratios (HRs) and 95% confidence intervals (CI).

Main Results:

  • MASLD developed in 8.9% of the strict-normal thyroid function group and 13.4% of the low thyroid function group.
  • Low thyroid function (HR 1.53) and subclinical hypothyroidism (HR 1.95) were significantly associated with MASLD.
  • The association remained statistically relevant (P < 0.05).

Conclusions:

  • MASLD is significantly associated with low thyroid function.
  • The relationship between MASLD and low thyroid function is independent.
  • Thyroid function is a relevant factor in MASLD development.