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Related Concept Videos

CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains delta-9-tetrahydrocannabinol (THC)...

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Related Experiment Video

Updated: Jul 9, 2026

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Psilocybin induces dose-dependent changes in functional network organization in rat cortex.

Brian H Silverstein1,2, Nicholas Kolbman1,2,3, Amanda Nelson1

  • 1Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109, USA.

Biorxiv : the Preprint Server for Biology
|February 26, 2024
PubMed
Summary

Psilocybin alters brain network dynamics in rats, dose-dependently disrupting theta-gamma coupling and increasing high-frequency connectivity. These changes in network organization may signify psilocybin-induced altered states of consciousness.

Keywords:
High gamma oscillationsPhase-Amplitude CouplingPsilocybinPsychedelicRatweighted Phase-Lag Index

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Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Computational Psychiatry

Background:

  • Psilocybin induces altered states of consciousness, necessitating rodent models to study brain network dynamics.
  • Previous rodent studies using electroencephalogram (EEG) lacked spatial resolution for network analysis and were limited to lower gamma frequencies.

Approach:

  • Utilized high-density EEG recordings from 27 cortical sites in rats to analyze psilocybin's effects on network organization.
  • Investigated changes in node degree and connection strength across theta, medium gamma, and high gamma frequency bands.
  • Examined alterations in theta-gamma phase-amplitude coupling and dose-dependent network effects.

Key Points:

  • Psilocybin dose-dependently disrupted theta-gamma coupling (p<0.05).
  • Increased frontal high gamma and posterior theta connectivity and network density (p<0.05).
  • Medium gamma frontoparietal connectivity exhibited a nonlinear dose-response relationship.

Conclusions:

  • Psilocybin significantly alters brain network organization in a dose-dependent manner.
  • High-frequency network activity, independent of theta phase, appears crucial for psilocybin-induced altered states.
  • This study provides a foundation for understanding psychedelic mechanisms in rodent models.