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Related Experiment Video

Updated: Jul 2, 2025

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
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Psilocybin induces dose-dependent changes in functional network organization in rat cortex.

Brian H Silverstein1,2, Nicholas Kolbman1,2,3, Amanda Nelson1

  • 1Department of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109, USA.

Biorxiv : the Preprint Server for Biology
|February 26, 2024
PubMed
Summary
This summary is machine-generated.

Psilocybin alters brain network dynamics in rats, dose-dependently disrupting theta-gamma coupling and increasing high-frequency connectivity. These changes in network organization may signify psilocybin-induced altered states of consciousness.

Keywords:
High gamma oscillationsPhase-Amplitude CouplingPsilocybinPsychedelicRatweighted Phase-Lag Index

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Area of Science:

  • Neuroscience
  • Psychopharmacology
  • Computational Psychiatry

Background:

  • Psilocybin induces altered states of consciousness, necessitating rodent models to study brain network dynamics.
  • Previous rodent studies using electroencephalogram (EEG) lacked spatial resolution for network analysis and were limited to lower gamma frequencies.

Approach:

  • Utilized high-density EEG recordings from 27 cortical sites in rats to analyze psilocybin's effects on network organization.
  • Investigated changes in node degree and connection strength across theta, medium gamma, and high gamma frequency bands.
  • Examined alterations in theta-gamma phase-amplitude coupling and dose-dependent network effects.

Key Points:

  • Psilocybin dose-dependently disrupted theta-gamma coupling (p<0.05).
  • Increased frontal high gamma and posterior theta connectivity and network density (p<0.05).
  • Medium gamma frontoparietal connectivity exhibited a nonlinear dose-response relationship.

Conclusions:

  • Psilocybin significantly alters brain network organization in a dose-dependent manner.
  • High-frequency network activity, independent of theta phase, appears crucial for psilocybin-induced altered states.
  • This study provides a foundation for understanding psychedelic mechanisms in rodent models.