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Somatic growth outcomes in response to an individualized neonatal sodium supplementation protocol

Lyndsay Harshman1, Elliot Stalter, Silvia Verhofste

  • 1University of Iowa Stead Family Department of Pediatrics.

Research Square
|February 26, 2024
PubMed

Insights

Protocolized sodium (Na) supplementation improved growth and reduced mechanical ventilation in extremely preterm infants. This approach enhanced weight and head circumference z-scores without increasing adverse morbidities.

Area of Science:

  • Neonatal Medicine
  • Pediatric Endocrinology
  • Clinical Nutrition

Background:

  • Preterm infants often require careful monitoring of electrolytes, including sodium (Na), to support growth and development.
  • Established protocols for sodium supplementation can be crucial for managing fluid and electrolyte balance in vulnerable newborns.
  • Urinary sodium concentration offers a potential biomarker for guiding individualized supplementation strategies.

Conclusions:

  • Protocolized sodium (Na) supplementation effectively improves growth metrics in extremely preterm infants (26-29 6/7 weeks GA).
  • The protocol is associated with a significant reduction in the duration of invasive mechanical ventilation for this population.
  • This Na supplementation strategy enhances key growth parameters without elevating the risk of common neonatal morbidities.
Abstract

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