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NF-κB Signaling is Required for X-Chromosome Inactivation Maintenance Following T cell Activation.

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    This summary is machine-generated.

    Female T cells use NF-κB signaling to maintain X chromosome inactivation (XCI). T cell activation triggers Xist RNA accumulation and epigenetic changes on the inactive X chromosome (Xi), impacting gene expression.

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    Area of Science:

    • Genetics
    • Immunology
    • Epigenetics

    Background:

    • X Chromosome Inactivation (XCI) balances gene dosage between sexes.
    • In unstimulated T cells, the inactive X chromosome (Xi) lacks specific RNA and epigenetic marks.
    • T cell stimulation leads to enrichment of these marks on the Xi.

    Conclusions:

    • NF-κB signaling is crucial for Xist RNA accumulation and XCI maintenance in female T cells.
    • Disrupting NF-κB signaling alters X-linked gene expression.
    • This study reveals a novel link between NF-κB signaling and XCI in T cells.