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Published on: December 2, 2012
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Gemykibivirus detection in acute encephalitis patients from Nepal
Eans Tara Tuladhar1, Smita Shrestha1, Susan Vernon2
1Tribhuvan University Central Department of Biotechnology, Kathmandu, Nepal.
Medrxiv : the Preprint Server for Health Sciences
|February 26, 2024
Summary
A novel gemykibivirus was identified in Nepalese children with Acute Encephalitis Syndrome (AES). This discovery offers a potential cause for unexplained encephalitis cases, improving diagnosis and treatment strategies.
Area of Science:
- Virology
- Neurology
- Infectious Diseases
Background:
- Acute Encephalitis Syndrome (AES) presents a significant global health challenge, causing substantial morbidity and mortality.
- In Nepal, Japanese encephalitis virus (JEV) is identified in only 5-20% of AES cases, leaving approximately 75% of cases with unknown etiology.
- The etiological agents responsible for the majority of AES cases in Nepal remain largely unidentified.
Conclusions:
- This study identifies a gemykibivirus as a potential causative agent of encephalitis in Nepal.
- The findings contribute to understanding the etiology of unexplained AES cases in the region.
- The developed PCR assays provide valuable diagnostic tools for future surveillance and clinical management.
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