ST-Segment Elevation Myocardial Infarction Caused by 5-Fluorouracil-Related Cardiotoxicity
Nivedha Balaji1, Priyadarshini Dixit2, Alex M Adams3
1Internal Medicine, Northeast Georgia Medical Center Gainesville, Gainesville, USA.
Cureus
|February 26, 2024
Summary
5-Fluorouracil (5-FU) chemotherapy can cause rare but serious cardiovascular toxicity, including myocardial infarction. Prompt recognition and discontinuation of 5-FU are crucial for managing these cardiac events.
Area of Science:
- Oncology
- Cardiology
Background:
- 5-Fluorouracil (5-FU) and capecitabine are standard chemotherapies for solid tumors.
- While generally well-tolerated, they can cause significant adverse effects.
- Cardiovascular toxicity is a less common but severe complication.
Observation:
- A 72-year-old male patient initiated 5-FU chemotherapy.
- The patient experienced coronary vasospasm and ST-segment elevation myocardial infarction.
- These cardiac events occurred shortly after starting 5-FU treatment.
Findings:
- 5-FU can induce coronary vasospasm.
- This vasospasm can lead to acute myocardial infarction.
- Cardiotoxicity is a critical consideration in 5-FU therapy.
Implications:
- Early identification of 5-FU-induced cardiotoxicity is vital.
- Discontinuation of 5-FU and appropriate medical management are essential.
- This case highlights the importance of monitoring cardiac function during 5-FU treatment.
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