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Related Concept Videos

Complement System01:27

Complement System

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The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
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Complementation Tests00:49

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A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
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Personality Disorders: Dependent and Obsessive-Compulsive01:24

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Dependent personality disorder and obsessive-compulsive personality disorder are two separate psychological conditions that influence behavior, relationships, and overall life functioning. Though both involve maladaptive behaviors, their core characteristics and motivations differ significantly.
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Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Related Experiment Video

Updated: Jul 2, 2025

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
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Complements and Their Role in Systemic Disorders.

Samuel Sherng Young Wang1, Haoming Tang2, Marcus Wing Choy Loe2

  • 1Nephrology, Tan Tock Seng Hospital, Singapore, SGP.

Cureus
|February 26, 2024
PubMed
Summary
This summary is machine-generated.

The complement system, vital for innate immunity, can be dysregulated in various diseases. Understanding its role aids in diagnosing and managing complement-mediated disorders.

Keywords:
acquired deficiencycomplementcongenital deficiencydiagnosispathophysiologysystemic diseasetherapeutics

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Area of Science:

  • Immunology
  • Pathophysiology

Background:

  • The complement system is a crucial part of innate immunity, involving classical, alternative, and lectin pathways.
  • Dysregulation of the complement system, due to congenital or acquired conditions, leads to specific deficiencies and contributes to various systemic diseases.

Purpose of the Study:

  • To review the role of complement factors in systemic diseases.
  • To guide clinicians in diagnosing and managing complement-mediated disorders.

Main Methods:

  • Literature review of complement system mechanisms and pathophysiology.
  • Analysis of complement's role in rheumatic, neurological, ophthalmological, renal, and hematological disorders.

Main Results:

  • Complement system dysregulation is implicated in a range of systemic diseases.
  • Understanding complement pathways is essential for clinical diagnosis and treatment.

Conclusions:

  • Adequate knowledge of complement mechanisms and dysregulation is critical for effective clinical management.
  • This review provides insights into diagnostic and therapeutic strategies for complement-mediated conditions.