Complements and Their Role in Systemic Disorders

Area of Science:

• Immunology
• Pathophysiology

Background:

• The complement system is a crucial part of innate immunity, involving classical, alternative, and lectin pathways.
• Dysregulation of the complement system, due to congenital or acquired conditions, leads to specific deficiencies and contributes to various systemic diseases.

Purpose of the Study:

• To review the role of complement factors in systemic diseases.
• To guide clinicians in diagnosing and managing complement-mediated disorders.

Main Methods:

• Literature review of complement system mechanisms and pathophysiology.
• Analysis of complement's role in rheumatic, neurological, ophthalmological, renal, and hematological disorders.

Main Results:

• Complement system dysregulation is implicated in a range of systemic diseases.
• Understanding complement pathways is essential for clinical diagnosis and treatment.

Conclusions:

• Adequate knowledge of complement mechanisms and dysregulation is critical for effective clinical management.
• This review provides insights into diagnostic and therapeutic strategies for complement-mediated conditions.