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Complements and Their Role in Systemic Disorders

Samuel Sherng Young Wang1, Haoming Tang2, Marcus Wing Choy Loe2

  • 1Nephrology, Tan Tock Seng Hospital, Singapore, SGP.

Cureus
|February 26, 2024
PubMed

Insights

The complement system, vital for innate immunity, can be dysregulated in various diseases. Understanding its role aids in diagnosing and managing complement-mediated disorders.

Area of Science:

  • Immunology
  • Pathophysiology

Background:

  • The complement system is a crucial part of innate immunity, involving classical, alternative, and lectin pathways.
  • Dysregulation of the complement system, due to congenital or acquired conditions, leads to specific deficiencies and contributes to various systemic diseases.

Purpose of the Study:

  • To review the role of complement factors in systemic diseases.
  • To guide clinicians in diagnosing and managing complement-mediated disorders.

Main Methods:

  • Literature review of complement system mechanisms and pathophysiology.
  • Analysis of complement's role in rheumatic, neurological, ophthalmological, renal, and hematological disorders.

Main Results:

  • Complement system dysregulation is implicated in a range of systemic diseases.
  • Understanding complement pathways is essential for clinical diagnosis and treatment.

Conclusions:

  • Adequate knowledge of complement mechanisms and dysregulation is critical for effective clinical management.
  • This review provides insights into diagnostic and therapeutic strategies for complement-mediated conditions.

Keywords:
acquired deficiencycomplementcongenital deficiencydiagnosispathophysiologysystemic diseasetherapeutics

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