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Updated: May 1, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

23.0K

Methicillin-Resistant Staphylococcus aureus Cellulitis Causing Meningitis From Hematogenous Dissemination: A Case

Omar M Masarweh1, Suhail Saad-Omer1, Michael Rohr2

  • 1Internal Medicine, University of Central Florida, Kissimmee, USA.

Cureus
|February 26, 2024
PubMed

Insights

Methicillin-resistant Staphylococcus aureus meningitis, a rare complication of diabetic foot infections, can spread through the bloodstream. This case highlights successful treatment with daptomycin and rifampin.

Area of Science:

  • Infectious Diseases
  • Neurology
  • Bacteriology

Background:

  • Methicillin-resistant Staphylococcus aureus (MRSA) meningitis is typically linked to neurosurgery.
  • Hematogenous dissemination of MRSA to the central nervous system is infrequently documented.

Observation:

  • A diabetic patient presented with a foot infection.
  • The infection led to a bloodstream infection (bacteremia).
  • The bacteremia resulted in multiple serious complications including endocarditis, discitis, and vertebral osteomyelitis.

Findings:

  • The patient developed MRSA meningitis secondary to the disseminated infection.
  • Cerebrospinal fluid analysis confirmed MRSA meningitis.
  • Infective endocarditis, discitis, and vertebral osteomyelitis were diagnosed concurrently.

Implications:

  • This case underscores the potential for diabetic foot infections to cause severe systemic MRSA infections, including meningitis.
  • Intravenous daptomycin combined with rifampin proved effective in treating this complex MRSA infection.
  • Highlights the importance of considering hematogenous spread in MRSA meningitis, especially in patients with risk factors like diabetes.
Keywords:
cellulitisinfectious diseasesmeningitismethicillin resistant staphylococcus aureus (mrsa)septic embolivalvular endocarditis

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