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Macrophage-Derived Exosomes as Advanced Therapeutics for Inflammation: Current Progress and Future Perspectives
Yanjuan Song1, Jing Hu2, Chunlian Ma3,4,5
1Graduate School, Wuhan Sports University, Wuhan, Hubei Province, People's Republic of China.
Abstract:
The development of numerous diseases is significantly influenced by inflammation. Macrophage-derived exosomes (M-Exos) play a role in controlling inflammatory reactions in various conditions, including chronic inflammatory pain, hypertension, and diabetes. However, the specific targets and roles of M-Exos in regulating inflammation in diseases remain largely unknown. This review summarizes current knowledge on M-Exos biogenesis and provides updated information on M-Exos' biological function in inflammation modulation. Furthermore, this review highlights the functionalization and engineering strategies of M-Exos, while providing an overview of cutting-edge approaches to engineering M-Exos and advancements in their application as therapeutics for inflammation modulation. Finally, multiple engineering strategies and mechanisms are presented in this review along with their perspectives and challenges, and the potential contribution that M-Exos may have in diseases through the modulation of inflammation is discussed.
Insights
Macrophage-derived exosomes (M-Exos) are key regulators of inflammation in diseases. This review explores their biogenesis, function, and therapeutic potential through engineering strategies for inflammation modulation.
Area of Science:
- Biomedical Sciences
- Cell Biology
- Immunology
Background:
- Inflammation significantly impacts disease development.
- Macrophage-derived exosomes (M-Exos) modulate inflammatory responses in conditions like pain, hypertension, and diabetes.
- The precise roles and targets of M-Exos in disease-related inflammation require further elucidation.
Purpose of the Study:
- To review current knowledge on M-Exos biogenesis and their function in inflammation modulation.
- To highlight strategies for functionalizing and engineering M-Exos for therapeutic applications.
- To discuss perspectives and challenges in M-Exos-based inflammation modulation.
Main Methods:
- Literature review of M-Exos biogenesis and function.
- Analysis of M-Exos engineering strategies and therapeutic advancements.
- Discussion of M-Exos mechanisms in disease through inflammation modulation.
Main Results:
- M-Exos possess significant potential in modulating inflammation.
- Engineering strategies offer promising avenues for therapeutic development.
- Understanding M-Exos' role in disease pathogenesis is crucial.
Conclusions:
- M-Exos are critical regulators of inflammation with therapeutic potential.
- Advanced engineering techniques enhance M-Exos efficacy for treating inflammatory diseases.
- Further research is needed to fully harness M-Exos for disease management.
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