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Dynamic changes in cardiac biomarkers in radiotherapy for oesophageal cancer and their correlations with cardiac radiation dosimetry

  • 0Shandong University Cancer Center, Jinan, Shandong Province 250012, PR China.
Clinical and Translational Radiation Oncology +

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February 26, 2024

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February 26, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Radiotherapy for esophageal cancer can cause cardiac injury, increasing cardiac enzymes like hs-TnT and pro-BNP while decreasing LVEF. Higher radiation doses worsen these effects, highlighting the need for monitoring cardiac markers during treatment.

Area Of Science

  • Cardiology
  • Oncology
  • Radiation Oncology

Background

  • Concurrent chemoradiotherapy (cCRT) for esophageal squamous cell carcinoma (ESCC) can impact cardiac function.
  • Dynamic changes in cardiac biomarkers and left ventricular ejection fraction (LVEF) during and after treatment are not fully understood.

Purpose Of The Study

  • To investigate dynamic changes in cardiac enzymes (hs-TnT, pro-BNP) and LVEF during and after radiotherapy for ESCC.
  • To analyze correlations between these cardiac indicators and radiation dosimetry parameters.

Main Methods

  • 35 ESCC patients receiving cCRT underwent intensity-modulated radiotherapy.
  • Cardiac markers (CK, CK-MB, LDH, α-HBDH, hs-TnT, pro-BNP) and LVEF were measured at multiple time points before, during, and up to 6 months post-RT.
  • Correlations with mean heart dose (MHD) and heart V5-V50 were analyzed.

Main Results

  • hs-TnT and pro-BNP increased, while LVEF decreased during and after RT, with prolonged effects in higher-dose groups (MHD ≥ 2000 cGy).
  • CK and CK-MB initially decreased then normalized.
  • MHD and V35 showed positive correlations with hs-TnT changes.

Conclusions

  • cCRT for ESCC can cause early cardiac injury, indicated by elevated hs-TnT/pro-BNP and reduced LVEF, particularly with higher radiation doses.
  • MHD and V35 may predict cardiac damage severity.
  • Dynamic monitoring of hs-TnT and pro-BNP is valuable for cardiac protection during esophageal cancer radiotherapy.

Keywords:

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