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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

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Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
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Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

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Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
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Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

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Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
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Introduction to Hemostasis01:05

Introduction to Hemostasis

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Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized,...
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Immunodeficiency Diseases01:25

Immunodeficiency Diseases

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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
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Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Updated: Jul 2, 2025

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
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ACQUIRED HAEMOPHILIA A.

Ewe Jin Koh1, Jenq Tzong Tan1, Nur Nadia Amalina Manan1

  • 1Department of Internal Medicine, Hospital Taiping, Perak, Malaysia.

Journal of Ayub Medical College, Abbottabad :, JAMC
|February 26, 2024
PubMed
Summary
This summary is machine-generated.

Acquired haemophilia A (AHA) is a rare autoimmune disorder where antibodies inhibit clotting Factor VIII. This case highlights AHA presenting as unexplained bruising, emphasizing diagnostic awareness for this serious bleeding condition.

Keywords:
Acquired haemophilia, mixing test, inhibitors, bleeding, elderly

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Area of Science:

  • Hematology
  • Immunology
  • Rare Diseases

Background:

  • Acquired haemophilia A (AHA) is a rare autoimmune disorder distinct from congenital hemophilias.
  • It arises from autoantibodies inhibiting clotting Factor VIII, leading to bleeding risks.
  • Prevalence is underestimated due to underdiagnosis, affecting approximately one in a million annually.

Observation:

  • This study details a case of AHA presenting with spontaneous, unprovoked bruising.
  • The patient had no prior history of bleeding disorders.
  • This presentation underscores the potential for severe bleeding in AHA.

Findings:

  • Autoantibody-mediated inhibition of Factor VIII is the cause of acquired haemophilia A.
  • Diagnosis requires a high index of suspicion, especially in patients with new bleeding issues.
  • Prompt recognition is crucial for effective management.

Implications:

  • Increased clinical awareness of AHA is needed to improve diagnosis rates.
  • Early detection and management can prevent life-threatening hemorrhage.
  • Understanding the autoimmune basis of AHA is key for therapeutic strategies.