Visual Biosensing with Specific Liquid-Based Interface Behaviors

Liquid-based interface behaviors at micro/nano or even smaller scales induced by biomolecules take us into a fascinating realm, fostering a deeper understanding and innovation in visual biosensing. This biosensing technology, grounded in specific liquid-based interface behaviors, redefines how diseases can be detected, monitored, and diagnosed in resource-limited settings, providing rapid, cost-effective, and self-testing solutions to the current healthcare landscape. To date, the technology has witnessed significant advancements in visual sensing, driven by diverse liquid-based materials, advanced nanomanufacturing techniques, and a profound understanding of interface-material interactions. In this Perspective, we discuss and elucidate the interface biosensing mechanisms arising from three types, including liquid-solid, liquid-liquid, and liquid-gas interfaces, and we provide insights into the challenges and future development of visual biosensing applications.