Related Experiment Video
Updated: Jul 19, 2026

Genome-wide Gene Deletions in Streptococcus sanguinis by High Throughput PCR
Published on: November 23, 2012
Molecular Epidemiology of Underreported Emerging Zoonotic Pathogen Streptococcus suis in Europe
Abstract:
Streptococcus suis, a zoonotic bacterial pathogen circulated through swine, can cause severe infections in humans. Because human S. suis infections are not notifiable in most countries, incidence is underestimated. We aimed to increase insight into the molecular epidemiology of human S. suis infections in Europe. To procure data, we surveyed 7 reference laboratories and performed a systematic review of the scientific literature. We identified 236 cases of human S. suis infection from those sources and an additional 87 by scanning gray literature. We performed whole-genome sequencing to type 46 zoonotic S. suis isolates and combined them with 28 publicly available genomes in a core-genome phylogeny. Clonal complex (CC) 1 isolates accounted for 87% of typed human infections; CC20, CC25, CC87, and CC94 also caused infections. Emergence of diverse zoonotic clades and notable severity of illness in humans support classifying S. suis infection as a notifiable condition.
More Related Videos
Related Concept Videos
Steps in Outbreak Investigation
Principles of Disease Surveillance
Modern Molecular Taxonomy
Infectious Diseases and Their Occurrence
Investigation of Disease Outbreaks
Clinical Significance of Antibiotic Resistance

