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Updated: Jul 2, 2025

Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function
Published on: April 26, 2024
Amino acid chiral amplification using Monte Carlo dynamic
Romulo Leoncio Cruz-Simbron1, Gino Picasso1, José Cerda-Hernández2
1Technology of Materials for Environmental Remediation (TecMARA) Research Group, Faculty of Sciences, National University of Engineering, Av. Tupac Amaru 210, Lima, Peru.
Abstract:
This study investigates the stability of chiral-molecule solution phases, with a specific focus on amino acids. The model framework is based on a two-dimensional square lattice model, where individual sites may be occupied by oriented chiral molecules or structureless solvent particles. Utilizing the Glauber dynamics and statistical mechanical formalism, as previously introduced and examined by Lombardo et al., we explore the influence of temperature, amino acid concentration, enantiomeric excess, and homochiral interaction strength on nucleation mechanisms, equilibrium phase behavior, and crystal composition. Our findings offer thermodynamic insights into the chiral amplification process of amino acids, contributing to a deeper understanding of the underlying processes.
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