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Updated: Jul 2, 2025

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

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Catheter ablation of atrial fibrillation in patients with left bundle branch block

Ri-Bo Tang1, Wen-He Lv1, De-Yong Long1

  • 1Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing, China.

Pacing and Clinical Electrophysiology : PACE
|February 26, 2024
PubMed

Insights

Patients with left bundle branch block (LBBB) undergoing atrial fibrillation (AF) ablation have higher recurrence rates and composite endpoint risks. LBBB is an independent risk factor for adverse outcomes post-AF catheter ablation.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Medical Devices

Background:

  • Left bundle branch block (LBBB) and atrial fibrillation (AF) frequently coexist.
  • The effect of LBBB on AF catheter ablation outcomes is not well understood.

Purpose of the Study:

  • To investigate the long-term results of catheter ablation for AF in patients with LBBB.

Main Methods:

  • Retrospective analysis of 42 patients with LBBB and 168 matched controls without LBBB who underwent AF ablation (2011-2020).
  • Propensity score matching was used to create comparable groups.
  • Comparison of late recurrence rates and a composite endpoint (stroke, mortality, cardiovascular hospitalization).

Main Results:

  • Late recurrence was significantly higher in the LBBB group (54.8%) versus the non-LBBB group (31.5%), p=0.034.
  • LBBB was an independent risk factor for late recurrence (HR 2.19, p=0.031).
  • The composite endpoint incidence was higher in the LBBB group (21.4%) compared to the non-LBBB group (6.5%), p=0.002.

Conclusions:

  • Left bundle branch block is associated with increased risk of late recurrence after AF catheter ablation.
  • Patients with LBBB undergoing AF ablation face a higher risk of adverse composite outcomes.
Abstract

Keywords:
atrial fibrillationcatheter ablationleft bundle branch block

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