A potential link between inflammatory profiles, clinical pain, pain catastrophizing and long-term outcomes after total knee arthroplasty surgery
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View abstract on PubMed
Summary
This summary is machine-generated.Five years after total knee replacement (TKR), low-grade inflammation may be linked to chronic pain, high pain catastrophizing, and poor function in some patients. This study explores inflammatory mediators associated with long-term TKR pain complications.
Area Of Science
- Orthopedics
- Pain Medicine
- Immunology
Background
- Chronic postoperative pain is a significant issue following total knee replacement (TKR).
- The role of specific inflammatory mediators in long-term TKR pain remains unclear.
Purpose Of The Study
- To evaluate inflammatory mediators five years after TKR in patients with varying pain levels.
- To investigate associations between these mediators and clinical pain intensity, cognitive, and functional outcomes.
Main Methods
- Plasma samples from 76 TKR patients were analyzed for 44 inflammatory markers five years post-surgery.
- Pain (VAS), pain catastrophizing (PCS), and knee function (OKS) were assessed.
- Patients were grouped by high/low scores for VAS, PCS, and OKS.
Main Results
- Twelve biomarkers correlated with pain intensity (VAS), four with pain catastrophizing (PCS), and three with knee function (OKS).
- Four markers differed between high and low chronic pain groups.
- Three markers were altered in high catastrophizers and three in patients with poor functional scores.
Conclusions
- A subset of patients may experience low-grade inflammation five years post-TKR, associated with high pain, catastrophizing, and low function.
- These findings offer insights into the mechanisms underlying long-term pain after TKR.
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