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Updated: Jul 2, 2025
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An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
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A potential link between inflammatory profiles, clinical pain, pain catastrophizing and long-term outcomes after
Rocco Giordano1,2, Camilla Capriotti2,3, Maria Carla Gerra3
1Department of Oral and Maxillofacial Surgery, Aalborg University Hospital, Aalborg, Denmark.
European Journal of Pain (London, England)
|February 26, 2024
Summary
Five years after total knee replacement (TKR), low-grade inflammation may be linked to chronic pain, high pain catastrophizing, and poor function in some patients. This study explores inflammatory mediators associated with long-term TKR pain complications.
Area of Science:
- Orthopedics
- Pain Medicine
- Immunology
Background:
- Chronic postoperative pain is a significant issue following total knee replacement (TKR).
- The role of specific inflammatory mediators in long-term TKR pain remains unclear.
Purpose of the Study:
- To evaluate inflammatory mediators five years after TKR in patients with varying pain levels.
- To investigate associations between these mediators and clinical pain intensity, cognitive, and functional outcomes.
Main Methods:
- Plasma samples from 76 TKR patients were analyzed for 44 inflammatory markers five years post-surgery.
- Pain (VAS), pain catastrophizing (PCS), and knee function (OKS) were assessed.
- Patients were grouped by high/low scores for VAS, PCS, and OKS.
Main Results:
- Twelve biomarkers correlated with pain intensity (VAS), four with pain catastrophizing (PCS), and three with knee function (OKS).
- Four markers differed between high and low chronic pain groups.
- Three markers were altered in high catastrophizers and three in patients with poor functional scores.
Conclusions:
- A subset of patients may experience low-grade inflammation five years post-TKR, associated with high pain, catastrophizing, and low function.
- These findings offer insights into the mechanisms underlying long-term pain after TKR.
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