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Flow determination using computed tomography: application to aortic dissection. Part I.

D F Guthaner, M Nassi, B Bradley

    Investigative Radiology
    |October 1, 1985
    PubMed
    Summary
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    This study validates a CT method for blood flow determination using contrast enhancement dynamics. The technique accurately characterizes flow parameters, showing good correlation in phantom models and potential for clinical application.

    Area of Science:

    • Medical Imaging
    • Hemodynamics
    • Radiology

    Background:

    • Accurate blood flow measurement is crucial in clinical diagnostics.
    • Current methods for flow determination have limitations.

    Purpose of the Study:

    • To evaluate a CT-based method for blood flow characterization.
    • To validate the technique using a phantom model and assess its clinical applicability.

    Main Methods:

    • Utilized contrast enhancement dynamics and indicator dilution curves.
    • Applied a perfect mixers-in-series model for curve fitting analysis.
    • Validated the method in a steady-state phantom model simulating in vivo conditions.

    Main Results:

    • Achieved good correlation (r = .85) between measured and actual flow rates.

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  • Demonstrated that variance decreased with increasing flow, while peak CT value increased.
  • The method successfully characterized blood flow in a simulated physiological environment.

    • Conclusions:

    • The CT method based on contrast enhancement dynamics is a viable approach for blood flow determination.
    • This technique allows for the characterization of hemodynamic parameters using intravenous contrast injection.
    • The validated method holds promise for clinical application in assessing blood flow.