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Prevalence and risk factors for cirrhotic cardiomyopathy: a prospective cross-sectional study
Huawei Xu1, Yu Zhang2, Yanjing Gao1
1Department of Gastroenterology.
Insights
Cirrhotic cardiomyopathy (CCM) affects 24.4% of patients with cirrhosis. Older age and portal vein thrombosis are key risk factors for CCM, independent of cirrhosis etiology.
Area of Science:
- Cardiology
- Hepatology
- Internal Medicine
Background:
- Cirrhosis significantly impacts cardiac structure and function.
- Cirrhotic cardiomyopathy (CCM) is a complex clinical syndrome in patients with liver cirrhosis.
- Understanding CCM prevalence and risk factors is crucial for patient management.
Purpose of the Study:
- To assess cardiac structure and function in patients with cirrhosis.
- To determine the prevalence of CCM across different etiologies of liver cirrhosis.
- To identify independent risk factors associated with CCM development.
Main Methods:
- Echocardiography was used to diagnose CCM in 131 hospitalized cirrhotic patients (aged 18-75).
- Patients with pre-existing heart conditions or other significant comorbidities were excluded.
- Demographic and clinical data were compared between CCM and non-CCM groups to identify risk factors.
Main Results:
- The overall prevalence of CCM was 24.4%.
- CCM prevalence was higher in patients with ascites (31.4%) and portal vein thrombosis (PVT) (42.9%).
- Older age (OR 1.058) and PVT (OR 2.999) were identified as independent risk factors for CCM.
Conclusions:
- CCM affects nearly a quarter of cirrhotic patients, irrespective of cirrhosis etiology.
- Ascites and PVT are associated with a higher prevalence of CCM.
- Older age and PVT are significant independent risk factors, warranting further investigation in larger cohorts.
Background:
This study aimed to assess cardiac structure and function in patients with cirrhosis, to investigate the prevalence of cirrhotic cardiomyopathy (CCM) in patients with cirrhosis of different etiologies and to analyze the risk factors for the development of CCM.
Methods:
This study selected cirrhotic patients aged 18-75 years who were hospitalized in Qilu Hospital of Shandong University. Patients with known heart disease, chronic lung disease, severe renal insufficiency, malignancy, thyroid disease, hypertension, diabetes or pregnancy were excluded. A total of 131 patients with cirrhosis were finally included. Based on the results of echocardiography, patients who met the diagnostic definition of CCM were included in the CCM group, otherwise, they were classified as the non-CCM group. The demographic and clinical data of the two groups were compared, and the clinical characteristics and risk factors of CCM were evaluated.
Results:
The overall prevalence of CCM was 24.4%, and the occurrence of CCM was not related to the etiology of liver cirrhosis. The prevalence of CCM was significantly higher among cirrhotic patients complicated with ascites (31.4% vs. 16.4%; P = 0.046) or with portal vein thrombosis (PVT) (42.9% vs. 17.1%; P = 0.003). Older age [odds ratio (OR) = 1.058; 95% confidence interval (CI), 1.005-1.113; P = 0.032] and PVT (OR = 2.999; 95% CI, 1.194-7.533; P = 0.019) were independent risk factors for the development of CCM.
Conclusion:
The prevalence of CCM in cirrhotic patients was 24.4%, and the occurrence of CCM was not related to the etiology of cirrhosis. The prevalence of CCM was higher in cirrhotic patients with ascites or PVT. Older age and PVT are independent risk factors for CCM, but validation in larger sample studies is still needed.
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