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Updated: Jul 2, 2025

Assessing Whole-Body Lipid-Handling Capacity in Mice

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

Newborn screening for lipid disorders.

Xiangqiang Shao¹, Robert Steiner¹, Amy L Peterson²

¹Department of Pediatrics, Division of Genetics and Metabolism.

Current Opinion in Lipidology

|February 26, 2024

Summary

This summary is machine-generated.

Newborn screening can now detect lipid disorders like familial hypercholesterolemia. Advances in testing methods, including next-generation sequencing, enable early identification of these conditions for improved public health outcomes.

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Area of Science:

Biochemistry
Genetics
Public Health

Background:

Newborn screening is a highly successful public health initiative.
Recent interest has grown in expanding newborn screening to include lipid disorders.
Early detection of lipid disorders has significant implications for affected newborns and their families.

Purpose of the Study:

To review recent advancements in newborn screening for lipid disorders.
To highlight the feasibility and potential public health impact of screening for conditions like familial hypercholesterolemia and cerebrotendinous xanthomatosis.

Main Methods:

Review of recent studies on biomarker measurement from newborn screening dried blood spots.
Evaluation of current assays for specific lipid disorders.
Assessment of next-generation sequencing technologies for primary newborn screening.

Main Results:

Biomarkers for heterozygous familial hypercholesterolemia can be measured from dried blood spots.
Cerebrotendinous xanthomatosis screening is feasible with existing assays.
Next-generation sequencing shows promise for identifying a broad range of common and rare lipid disorders.

Conclusions:

Newborn screening for lipid disorders is becoming increasingly feasible.
Technological advancements are expanding the scope of detectable lipid disorders.
Expanded newborn screening for lipid disorders has the potential to improve individual and public health.