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Published on: March 7, 2017
Pediatric Hodgkin's disease in India
Summary
Pediatric Hodgkin's disease in India is common, with most cases presenting in advanced stages. Treatment evolved from individualized approaches to chemotherapy and radiation, showing shifts in management over time.
Area of Science:
- Pediatric Oncology
- Hematology
- Clinical Epidemiology
Background:
- Hodgkin's disease represents a significant portion of pediatric cancers in India.
- Tata Memorial Hospital data reveals 21% of Hodgkin's disease cases were in pediatric patients.
Purpose of the Study:
- To review and analyze pediatric Hodgkin's disease cases treated at Tata Memorial Hospital.
- To compare treatment strategies and outcomes between two distinct periods (1975-1978 and 1979-1982).
Main Methods:
- Retrospective review of 151 pediatric Hodgkin's disease cases from 1975 to 1982.
- Analysis of clinical staging, histologic subtypes, treatment protocols, and staging laparotomy outcomes.
- Comparison of individualized treatment (1975-1978) versus chemotherapy and radiation (1979-1982).
Main Results:
- A male predominance (5.5:1) and a youngest presentation at 3 years were observed.
- 54% of patients presented with Stages I and II disease, while 46% had advanced Stages III and IV.
- Mixed cell type (46%) and lymphocytic predominant (31%) were the most common histologic subtypes.
Conclusions:
- Pediatric Hodgkin's disease in India frequently presents at advanced stages.
- Treatment shifted towards chemotherapy and involved field radiation in later years.
- Further research is needed to optimize pediatric Hodgkin's disease management.
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