Global gene expression profile of proliferative verrucous leukoplakia and its underlying biological disease mechanisms
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Proliferative verrucous leukoplakia (PVL) is distinct from conventional leukoplakia, with unique gene expression patterns. This research identifies potential biomarkers for diagnosing PVL, a precursor to oral squamous cell carcinoma.
Area Of Science
- Oral pathology
- Molecular biology
- Cancer research
Background
- Proliferative verrucous leukoplakia (PVL) is a rare oral potentially malignant disorder.
- PVL invariably progresses to oral squamous cell carcinoma (OSCC).
Purpose Of The Study
- Characterize PVL gene expression using transcriptome profiling.
- Identify biomarkers for PVL diagnosis.
- Elucidate the molecular pathogenesis of PVL.
Main Methods
- Transcriptome profiling via RNA sequencing of 43 oral mucosal biopsies.
- Analysis included hierarchical clustering, differential gene expression, and network analysis.
- Sparse partial least squares discriminant analysis (sPLS-DA) and immune cell phenotypic estimation were employed.
Main Results
- Identified 464 differentially expressed genes between PVL and non-PVL oral leukoplakia (OLK).
- Upregulated genes in PVL include HOX genes, KRTAPs, and olfactory receptors.
- PVL showed downregulated connective tissue signaling and distinct immune cell profiles compared to OLK.
Conclusions
- PVL and conventional OLK are molecularly distinct.
- Upregulation of cancer-associated genes observed in PVL.
- Biomarker-based diagnostics are feasible for PVL discrimination and management.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...