Related Experiment Video

Updated: May 5, 2026

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
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Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

Published on: November 13, 2016

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Encyclopaedic Review of Glipizide Pre-clinical and Clinical Status

Saad Mohammed1, Tarique Mahmood1, Arshiya Shamim1

  • 1Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh, India.

Drug Research
|February 26, 2024
PubMed

Insights

Glipizide, an oral diabetes drug, shows potential in treating cancer and neurodegenerative diseases. However, it carries risks like DNA damage and increased mortality in certain patients.

Area of Science:

  • Pharmacology
  • Endocrinology
  • Oncology

Background:

  • Glipizide is an oral glucose-lowering medication for type 2 diabetes.
  • This review compiles preclinical and clinical data on glipizide's diverse applications.

Purpose of the Study:

  • To comprehensively review glipizide's therapeutic potential and risks across various conditions.
  • To explore glipizide's efficacy beyond diabetes treatment, including cancer and neurodegenerative disorders.

Main Methods:

  • Literature review of preclinical and clinical studies on glipizide.
  • Analysis of glipizide's interactions with other drugs and genetic variants.
  • Evaluation of glipizide's effects on angiogenesis, vasculogenesis, and cellular damage.

Main Results:

  • Glipizide shows potential in treating cancer and neurodegenerative diseases, and may enhance glycemic control when combined with certain agents.
  • In vitro studies indicate glipizide suppresses angiogenesis and vasculogenesis, and protects against glycation.
  • In vivo studies reveal anticonvulsant effects, altered pharmacokinetics of other drugs, and potential DNA damage with long-term use.

Conclusions:

  • Glipizide exhibits promising therapeutic efficacy in various disorders, but requires careful consideration of potential risks.
  • Further research is needed to fully understand glipizide's mechanisms and optimize its use in different therapeutic contexts.
  • Risk factors such as genetic variations and co-administration with certain drugs necessitate individualized treatment approaches.

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