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Updated: Jul 2, 2025

A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Waterhouse-Friderichsen syndrome, septic adrenal apoplexy
Rishikesh Rijal1, Kamal Kandel2, Barun Babu Aryal3
1University of Louisville School of Medicine, Louisville, KY, United States.
Abstract:
Waterhouse-Friderichsen syndrome is a rare but potentially fatal disorder of the adrenal gland characterized by bilateral adrenal hemorrhage. It is classically a result of meningococcal sepsis and presents acutely with features of shock, petechial rashes, abdominal pain, and non-specific symptoms such as headache, fatigue, and vomiting. Treatment consists of fluid resuscitation, corticosteroid replacement, and possibly surgery. The prognosis is poor despite treatment. This chapter will review the etiology, pathogenesis, clinical features, and management of the disease.
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