Association between the trajectory of ideal cardiovascular health metrics and incident chronic kidney disease among 27,635 older adults in northern China-a prospective cohort study
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View abstract on PubMed
Summary
This summary is machine-generated.Maintaining good cardiovascular health (CVH) in older adults is linked to a lower risk of developing chronic kidney disease (CKD). Improving CVH metrics can help prevent CKD in this population.
Area Of Science
- Gerontology
- Nephrology
- Cardiology
- Public Health
Background
- Limited research exists on the long-term effects of cardiovascular health (CVH) metrics on chronic kidney disease (CKD) progression.
- Understanding these long-term impacts is crucial for developing effective preventive strategies.
Purpose Of The Study
- To analyze long-term changes in CVH metrics among older adults.
- To investigate the association between CVH metric trajectories and the risk of developing CKD.
Main Methods
- Utilized data from 27,635 older adults in the Tianjin Chronic Kidney Disease Cohort study.
- Employed group-based trajectory modeling to identify CVH metric patterns and logistic regression to assess CKD risk.
- Validated findings through sensitivity analyses and likelihood ratio tests comparing different predictive models.
Main Results
- Identified six distinct CVH metric trajectories, with higher trajectories correlating to a significantly reduced risk of CKD (P < 0.001).
- Participants in the 'high-stable' CVH group had a 46% lower CKD risk compared to the 'low-stable' group.
- CVH trajectory models demonstrated superior predictive power for CKD risk compared to baseline CVH or changes in CVH (ΔCVH).
Conclusions
- Higher CVH metric trajectories and improvements in CVH are associated with a decreased risk of CKD in older adults.
- Emphasizes the critical role of enhancing cardiovascular health for the primary prevention of CKD in the elderly population.
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