Epidemiology and prognostic nomogram for chronic eosinophilic leukemia: a population-based study using the SEER...

Area of Science:

• Hematology
• Oncology
• Epidemiology

Background:

• Chronic Eosinophilic Leukemia (CEL) is a rare hematological disorder marked by uncontrolled eosinophil proliferation.
• Its infrequency poses diagnostic and therapeutic challenges.

Purpose of the Study:

• To investigate the epidemiology of CEL.
• To develop and validate a prognostic nomogram for predicting overall survival in CEL patients.

Main Methods:

• Analysis of the Surveillance, Epidemiology and End Results (SEER) database (2001-2020).
• Utilized LASSO and Cox regression for prognostic factor identification.
• Developed and validated a nomogram using training and validation cohorts.

Main Results:

• CEL incidence is low (0.033/100,000 person-years), increasing with age and higher in males.
• Advanced age, specific marital statuses, and secondary CEL were adverse prognostic factors.
• The nomogram showed good calibration and discrimination for risk stratification.

Conclusions:

• This study provides crucial epidemiological insights and a validated prognostic tool for CEL.
• The nomogram aids in personalized prognostication and risk stratification.
• Further research is needed for molecular mechanisms and treatment optimization.