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Related Concept Videos

Statistical Methods for Analyzing Epidemiological Data01:25

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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Association Between Smoking And Alcohol Drinking And Benign Adrenal Tumors: A Mendelian Randomization Study.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Association Between Smoking And Alcohol Drinking And Benign Adrenal Tumors: A Mendelian Randomization Study.

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Association between smoking and alcohol drinking and benign adrenal tumors: a Mendelian randomization study.

Kun Peng1, Qingyuan Liu1, Ning Wang1

  • 1Department of Urology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, 450003, China.

Endocrine
|February 27, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Smoking, particularly pack years and cigarettes per day, causally increases the risk of benign adrenal tumors. Alcohol consumption, however, shows no causal link to these tumors.

Keywords:
Adrenal tumorAlcohol drinkingMendelian randomizationSingle nucleotide polymorphism

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Area of Science:

  • Endocrinology
  • Genetics
  • Epidemiology

Background:

  • Increased detection rates of adrenal tumors necessitate understanding risk factors.
  • The relationship between smoking, alcohol, and benign adrenal tumors remains unclear.

Purpose of the Study:

  • To investigate the causal relationship between smoking, alcohol consumption, and benign adrenal tumors using Mendelian randomization (MR).

Main Methods:

  • Utilized large-scale genome-wide association study (GWAS) data for smoking and alcohol consumption.
  • Employed Mendelian randomization (MR) with inverse variance weighting (IVW), MR-Egger, and weighted median estimation (WME).
  • Conducted sensitivity analyses to ensure robustness of findings.

Main Results:

Smoking
  • Smoking, specifically pack years and cigarettes per day, demonstrated a causal risk for benign adrenal tumors (OR=2.853, P=0.004; OR=1.543, P=0.004).
  • No causal relationship was found between general smoking status, alcohol drinking status, or various measures of alcohol intake and benign adrenal tumors.
  • Specific single nucleotide polymorphisms (SNPs) rs8042849 and rs8034191 were identified as key drivers of the observed causal effects.

Conclusions:

  • Mendelian randomization analysis indicates a causal link between smoking habits and benign adrenal tumors.
  • Alcohol consumption does not appear to have a causal effect on the development of benign adrenal tumors.