Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Modeling and BASIC program for the kinetics of inhalation anesthetic agents].

H Deriaz, A Lienhart, P Viars

    Annales Francaises D'Anesthesie Et De Reanimation
    |January 1, 1985
    PubMed
    Summary

    Eger's model describes inhaled anesthetic pharmacokinetics using a lung model and four compartments. A computer program simulates anesthetic concentrations and compares induction/recovery times for different agents.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Onset of acquired haemophilia A after omalizumab treatment in severe bullous pemphigoid - a report on two cases successfully treated with mycophenolate mofetil.

    Annales de dermatologie et de venereologie·2021
    Same author

    Efficacy and safety of long-acting recombinant fusion protein linking factor IX with albumin in haemophilia B patients undergoing surgery.

    Haemophilia : the official journal of the World Federation of Hemophilia·2016
    Same author

    [Law on anesthesia safety in France: 20 years after].

    Annales francaises d'anesthesie et de reanimation·2014
    Same author

    Diagnosis and management challenges in patients with mild haemophilia A and discrepant FVIII measurements.

    Haemophilia : the official journal of the World Federation of Hemophilia·2014
    Same author

    Critical appraisal of organ procurement under Maastricht 3 condition.

    Annales francaises d'anesthesie et de reanimation·2014
    Same author

    SURgical interventions with FEIBA (SURF): international registry of surgery in haemophilia patients with inhibitory antibodies.

    Haemophilia : the official journal of the World Federation of Hemophilia·2013

    Area of Science:

    • Pharmacology
    • Anesthesiology
    • Physiology

    Background:

    • Eger's model provides a framework for understanding inhaled anesthetic pharmacokinetics.
    • The model simplifies lung physiology into a single alveolus with continuous ventilation.
    • It incorporates four extrapulmonary compartments based on blood supply and anesthetic solubility.

    Purpose of the Study:

    • To present Eger's pharmacokinetic model for inhaled anesthetics, including its equations.
    • To introduce a BASIC microcomputer program for simulating the model.
    • To compare induction and recovery times of different inhaled anesthetics under standardized conditions.

    Main Methods:

    • Utilized Eger's pharmacokinetic model with a monoalveolar lung and four compartments.
    • Developed a BASIC microcomputer program to calculate anesthetic concentrations.

    Related Experiment Videos

  • Simulated anesthetic uptake and distribution for agents like nitrous oxide.
  • Compared induction and recovery times across various inhaled anesthetics.

    • Main Results:

    • The study presents the equations governing Eger's pharmacokinetic model.
    • The microcomputer program can predict anesthetic concentrations under varied administration, ventilation, and cardiac output scenarios.
    • Comparative data on induction and recovery times for different inhaled anesthetics were generated.

    Conclusions:

    • Eger's model offers a robust method for describing inhaled anesthetic pharmacokinetics.
    • The proposed microcomputer program facilitates the simulation and prediction of anesthetic behavior.
    • The study provides valuable comparative data for selecting inhaled anesthetics based on clinical timing.