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Migraine and atrial fibrillation: a systematic review and meta-analysis

Camelia Qi En Lim1, Yao Neng Teo2, Tony Yi-Wei Li3

  • 1School of Medicine, Monash University, Melbourne, Australia.

Singapore Medical Journal
|February 27, 2024
PubMed
Abstract

Insights

This study found a low prevalence of atrial fibrillation in patients experiencing migraines. Further research is recommended to fully understand the connection between migraine and atrial fibrillation.

Area of Science:

  • Neurology
  • Cardiology
  • Epidemiology

Background:

  • Migraine, especially with aura, can be associated with stroke.
  • Atrial fibrillation is a recognized risk factor for stroke.
  • Shared pathophysiological mechanisms may link migraines and atrial fibrillation.

Purpose of the Study:

  • To systematically review and meta-analyze the association between migraine and atrial fibrillation.
  • To determine the prevalence of atrial fibrillation in individuals with migraine.

Main Methods:

  • Comprehensive literature search across EMBASE, PubMed, Scopus, and Cochrane databases up to September 5, 2022.
  • Inclusion of cohort and cross-sectional studies of adults (≥18 years) examining the migraine-atrial fibrillation link.
  • Exclusion of case-control studies and individuals with pre-existing atrial fibrillation or nonmigrainous headaches; quality assessed using the Newcastle-Ottawa Scale.

Main Results:

  • Six studies were included in the meta-analysis.
  • Pooled prevalence of atrial fibrillation was 1.61% in migraine with aura and 1.32% in migraine without aura.
  • The overall prevalence of atrial fibrillation in migraine patients was 1.39%.

Conclusions:

  • The prevalence of atrial fibrillation among migraine patients is low.
  • Additional research is necessary to elucidate the relationship between migraine and atrial fibrillation.
Keywords:
Atrial fibrillationmigrainestroke

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