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TG/HDL-c ratio as a predictor of progressive infarction in patients with anterior circulation single subcortical
Jing Lin1, Liangbin Dong2, Qin Huang1
1Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Insights
The triglyceride to high-density lipoprotein cholesterol (TG/HDL-c) ratio is linked to progressive infarction (PI) in patients with anterior circulation single subcortical infarction (ACSSI). A TG/HDL-c ratio of 3.985 or higher may predict PI in ACSSI patients.
Area of Science:
- Neurology
- Cardiovascular Research
- Biochemistry
Background:
- Progressive infarction (PI) prediction in anterior circulation single subcortical infarction (ACSSI) and pontine single infarction (PSI) is complex.
- The role of the triglyceride to high-density lipoprotein cholesterol (TG/HDL-c) ratio in PI remains unclear.
Purpose of the Study:
- To evaluate the correlation between the TG/HDL-c ratio and PI in patients with ACSSI or PSI.
Main Methods:
- Retrospective analysis of 738 patients (638 ACSSI, 100 PSI) from January 2020 to October 2022.
- Collection of demographic, clinical, and laboratory data within 24 hours of admission.
Main Results:
- Progressive infarction (PI) occurred in 19.4% of patients.
- Patients with PI exhibited higher TG/HDL-c ratios, NIHSS scores, and other lipid parameters.
- The TG/HDL-c ratio was independently associated with PI in ACSSI patients (OR 1.079, p=0.026), with an optimal predictive cutoff of 3.985.
Conclusions:
- The TG/HDL-c ratio is an independent predictor of PI in patients with ACSSI.
- A TG/HDL-c ratio ≥3.985 increases the likelihood of PI in ACSSI patients.
Background:
The contributors predicting progressive infarction (PI) in patients with anterior circulation single subcortical infarction (ACSSI) and pontine single infarction (PSI) may be unidentical. The role of triglyceride to high-density lipoprotein cholesterol (TG/HDL-c) ratio on PI is unclear. The purpose of our study is to evaluate the correlation between TG/HDL-c ratio and PI in patients with ACSSI or PSI.
Methods:
Between January 2020 and October 2022, we retrospectively enrolled 738 patients including 638 ACSSI patients and 100 PSI patients to analyze. Demographic characteristics, clinical information, and laboratory data were collected within 24 h of admission.
Results:
PI occurred in 143 (19.4%) patients. In univariate analysis, patients with PI had higher initial National Institutes of Health Stroke Scale (NIHSS) scores, higher discharge NIHSS scores, higher levels of fasting glucose, total cholesterol, TG, low-density lipoprotein cholesterol, and TG/HDL-c ratio, but lower levels of creatinine compared to patients with non-PI (p < .05). Furthermore, the results of the subgroup analyses revealed the independent association between TG/HDL-c ratio and PI in ACSSI patients (OR 1.079, 95% CI 1.009-1.153, p = .026) rather than in PSI patients. Additionally, a receiver operating characteristic curve indicated that the optimal predictive cutoff value of the TG/HDL-c ratio was 3.985, and a TG/HDL-c ratio ≥3.985 was more likely to experience PI in ACSSI patients.
Conclusion:
In conclusion, the TG/HDL-c ratio was independently associated with PI in patients with ACSSI.
