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Complexity of Translating Analytics to Recent Cannabis Use and Impairment
Michael W DeGregorio1,2, Chiao-Jung Kao1, Gregory T Wurz1
1RCU Labs, Inc., 408 Sunrise Ave, Roseville, CA 95661-4123, United States.
Journal of AOAC International
|February 27, 2024
Summary
Accurately detecting recent cannabis use within the impairment window is challenging due to limitations in current testing methods. A new approach using breath and blood analysis offers a more precise solution for identifying recent cannabis impairment.
Area of Science:
- Forensic Science
- Analytical Chemistry
- Toxicology
Background:
- Current methods for detecting cannabis use often fail to pinpoint recent use within the critical impairment window.
- Existing tests for delta-9-tetrahydrocannabinol (Δ9-THC) and its metabolites in bodily fluids can produce false positives due to prolonged detection times.
- The rise of hemp-derived products, including cannabidiol (CBD) and delta-8-tetrahydrocannabinol (Δ8-THC), complicates accurate cannabis use detection.
Purpose of the Study:
- To address the scientific limitations of current cannabis use detection methods, particularly concerning recent use and impairment.
- To develop and validate a novel analytical approach capable of accurately identifying recent cannabis consumption within the impairment window.
- To differentiate between various THC isomers and avoid false positives arising from legal hemp-derived products.
Main Methods:
- Development of a new testing methodology utilizing exhaled breath and blood sampling.
- Incorporation of kinetic changes and analysis of key cannabinoids in the testing approach.
- Focus on distinguishing between different THC isomers to improve accuracy.
Main Results:
- The new method demonstrates the ability to detect recent cannabis use within the impairment window.
- This approach avoids the false-positive results commonly associated with traditional Δ9-THC testing.
- It provides a more scientifically justified means of assessing recent cannabis impairment.
Conclusions:
- A comprehensive testing strategy combining breath and blood analysis is necessary for accurate detection of recent cannabis use and potential impairment.
- This novel method offers a scientifically sound solution to the challenges posed by current analytical techniques and evolving cannabis products.
- The findings support the accurate identification of impaired cannabis users while protecting responsible users from unjust consequences.
