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Effect of Honey and Aqueous Garlic Extracts against Short-Term Exposure of Cigarette Tobacco Smoking in Mice:
Ziad Shraideh1, Darwish Badran2, Ahmed Alzbeede3
1Department of Biological Sciences, School of Science, The University of Jordan, Amman 11942, Jordan.
Journal of Toxicology
|February 27, 2024
Summary
Honey and garlic extracts offer significant protection against the damaging effects of cigarette smoke on the liver, kidney, and jejunum. These natural compounds help reduce oxidative stress and preserve organ integrity following short-term smoke exposure.
Area of Science:
- Biochemistry
- Histology
- Toxicology
Background:
- Cigarette smoking is a major health concern, inducing oxidative stress and damaging vital organs.
- Understanding the protective mechanisms of natural compounds against smoking-induced damage is crucial.
Purpose of the Study:
- To evaluate the protective effects of honey and garlic extracts against short-term cigarette smoke exposure.
- To assess biochemical, histological, and ultrastructural changes in mice exposed to cigarette smoke and treated with honey or garlic.
Main Methods:
- Forty-eight mice were divided into six groups, with exposure to fresh air, cigarette smoke, or cigarette smoke combined with honey or garlic extracts for 21 days.
- Biochemical analysis of blood, and histological and ultrastructural examination of liver, kidney, and jejunum tissues were performed.
- Oxidative stress biomarkers were measured.
Main Results:
- Cigarette smoke exposure elevated carbonyl protein content and cystatin C, while decreasing albumin levels.
- Histological and ultrastructural studies revealed that honey and garlic extracts protected the liver, kidney, and jejunum.
- Treatment with honey and garlic extracts lowered oxidative stress biomarkers.
Conclusions:
- Honey and garlic extracts demonstrate protective potential against cigarette smoke-induced organ damage.
- These natural extracts can mitigate the adverse biochemical and histological effects of smoking.
- Honey and garlic represent a promising natural intervention for reducing smoking-related health risks.
