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PTX3 promotes breast cancer cell proliferation and metastasis by regulating PKCζbreast cancer, pentraxin 3, protein kinase Cζ, proliferation, metastasis

  • 0Clinical Laboratory, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Institute of Hepatobiliary Disease, Artificial Cell Engineering Technology Research Center, The Third Central Hospital of Tianjin, Tianjin 300170, P.R. China.
Experimental and Therapeutic Medicine +

|

February 27, 2024

|

February 27, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Pentraxin 3 (PTX3) promotes breast cancer (BC) growth and spread by regulating protein kinase C ζ (PKCζ) activation. PTX3 elevates BC cell proliferation, migration, and metastasis, offering potential therapeutic targets.

Area Of Science

  • Oncology
  • Molecular Biology
  • Biochemistry

Background

  • Breast cancer (BC) is a leading cause of cancer death in women.
  • Pentraxin 3 (PTX3) and protein kinase C ζ (PKCζ) are implicated in tumor progression.

Purpose Of The Study

  • To investigate the interaction between PTX3 and PKCζ in breast cancer.
  • To elucidate their roles in promoting BC proliferation and metastasis.

Main Methods

  • Assessed PTX3 expression in BC patients and cells.
  • Performed PTX3 knockdown experiments in BC cell lines (MDA-MB-231, MCF7).
  • Utilized co-localization and co-translocation assays to study PTX3 and PKCζ interaction.

Main Results

  • Elevated PTX3 expression in BC, correlating with lymph node metastasis.
  • PTX3 knockdown reduced BC cell proliferation, metastasis, and actin polymerization.
  • PTX3 and PKCζ co-localize and co-translocate; PTX3 regulates PKCζ phosphorylation and membrane translocation.
  • PTX3 promotes BC cell migration, chemotaxis, invasion, and adhesion via PKCζ activation.

Conclusions

  • PTX3 promotes breast cancer proliferation and metastasis.
  • PTX3 regulates PKCζ activation, enhancing key processes in BC progression.
  • PTX3 represents a potential therapeutic target for breast cancer treatment.

Keywords:

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