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A Blood-based Test for the Detection of ROS1 and RET Fusion Transcripts from Circulating Ribonucleic Acid Using Digital Polymerase Chain Reaction

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Ring Finger Protein 34 (RNF34) as a Prognostic Biomarker for Clear Cell Renal Cell Carcinoma.

Johannes Stein^1,2, Niklas Klümper^1,2, Pirmin Zöhrer^1,2

¹Urology, University Hospital Bonn, University of Bonn, Bonn, DEU.

|February 27, 2024

Summary

Ring finger protein 34 (RNF34) is upregulated in clear cell renal cell carcinoma (ccRCC) and associated with poor prognosis. RNF34 may serve as a novel prognostic biomarker for ccRCC patients.

Keywords:

biomarker clear cell renal cell carcinoma immunohistochemistry renal cell carcinoma rnf34 tcga

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Area of Science:

Oncology
Molecular Biology
Biomarker Discovery

Background:

Ring finger proteins are involved in cellular processes and cancer.
Ring finger protein 34 (RNF34) exhibits antiapoptotic and oncogenic properties.
RNF34 is upregulated in colorectal cancer but its role in clear cell renal cell carcinoma (ccRCC) is unknown.

Purpose of the Study:

To investigate the expression patterns and prognostic significance of RNF34 in ccRCC.
To determine the association of RNF34 expression with clinicopathological parameters and patient survival.

Main Methods:

Analysis of RNF34 mRNA expression in The Cancer Genome Atlas (TCGA) ccRCC cohort (N=533).
Immunohistochemical (IHC) staining of RNF34 protein in a ccRCC cohort (N=109).
Correlation of RNF34 expression with clinicopathological parameters and overall survival using Kaplan-Meier and Cox regression analyses.

Main Results:

RNF34 expression correlates with adverse clinicopathological parameters in ccRCC.
Higher RNF34 expression is associated with significantly shortened patient survival.
RNF34 expression is identified as an independent prognostic parameter in ccRCC.

Conclusions:

RNF34 is a potential prognostic biomarker for ccRCC.
RNF34 likely plays a significant role in the carcinogenesis of renal cell carcinoma.