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Related Experiment Video

Updated: Jun 16, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
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Long-range connections damage in white matter hyperintensities affects information processing speed.

Tong Lu1, Zan Wang2, Yixin Zhu2

  • 1Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.

Brain Communications
|February 27, 2024
PubMed
Summary

White matter hyperintensities disrupt brain networks, particularly long-range connections in hub regions. This connectivity impairment correlates with cognitive decline in patients with cerebral small vessel disease.

Keywords:
cerebral small vessel diseasecognitive impairmentconnectomefunctional connectivitywhite matter hyperintensities

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Cognitive Neurology

Background:

  • White matter hyperintensities (WMH) are key markers of cerebral small vessel disease.
  • WMH disrupt neuronal networks, contributing to cognitive dysfunction.
  • Understanding WMH effects on brain hub connectivity is crucial for elucidating cognitive impairment.

Purpose of the Study:

  • To investigate how WMH impact brain hub connectivity patterns.
  • To explore the relationship between disrupted connectivity and cognitive function in WMH patients.
  • To identify specific brain regions and connection types affected by WMH.

Main Methods:

  • Utilized a voxel-based graph-theory approach to analyze functional connectivity strength.
  • Compared 36 patients with moderate to severe WMH (Fazekas score ≥ 3) against 34 healthy controls.
  • Conducted comprehensive neuropsychological assessments and resting-state functional MRI scans.

Main Results:

  • WMH patients exhibited significant deficits in episodic memory, executive function, and processing speed.
  • WMH selectively impaired highly connected hub regions, including prefrontal cortex, precuneus, and thalamus.
  • Connectivity disruptions were distance-dependent, with long-range connections (100-150 mm) most affected.

Conclusions:

  • Disrupted hub connectivity, especially in long-range connections, is a key mechanism linking WMH to cognitive dysfunction.
  • The findings highlight the vulnerability of specific brain hubs and long-range networks in cerebral small vessel disease.
  • Targeting these connectivity disruptions may offer therapeutic avenues for cognitive impairment in WMH patients.