Related Experiment Video

Updated: Jul 2, 2025

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

17.5K

Auxological, Clinical, and MRI Abnormalities in Pediatric Patients With Isolated Growth Hormone Deficiency

Naseem Y Alyahyawi1

  • 1Pediatric Department, Faculty of Medicine, King Abdulaziz University, Jeddah, SAU.

Cureus
|February 27, 2024
PubMed

Insights

Pediatric patients with isolated growth hormone deficiency (GHD) show significant growth impairment. Brain MRI is recommended for severe GHD cases, as abnormalities are more common and linked to lower growth hormone levels.

Area of Science:

  • Pediatric Endocrinology
  • Neuroimaging
  • Growth Disorders

Background:

  • Isolated growth hormone deficiency (GHD) is a condition affecting childhood growth.
  • Understanding the clinical and radiological features of GHD is crucial for diagnosis and management.
  • Auxological and neuroradiological assessments are key components in evaluating pediatric GHD.

Purpose of the Study:

  • To assess auxological, clinical, and MRI features in pediatric patients with isolated GHD.
  • To analyze demographic and clinical characteristics of the study cohort.
  • To identify potential structural abnormalities contributing to GHD through MRI.

Main Methods:

  • A cohort of 115 pediatric patients with isolated GHD was studied.
  • Data collected included auxological measures (height, weight, bone age) and demographic information.
  • Brain MRI was used to evaluate the hypothalamic-pituitary region for structural abnormalities.

Main Results:

  • The cohort (67% male) had a mean age of 9.55 years with delayed bone age (7.37 years) and significant growth impairment (height SD -2.45).
  • Brain MRI revealed abnormalities in 12% of patients, with a higher prevalence (21%) in those with severe GHD.
  • Patients with abnormal MRI findings had significantly lower peak growth hormone (GH) levels (3.2 ng/mL) compared to those with normal MRI (6.02 ng/mL).

Conclusions:

  • Children with isolated GHD present with significant growth impairment and characteristic clinical features.
  • Neuroradiological abnormalities are frequently observed in severe isolated GHD.
  • MRI of the pituitary gland is recommended for patients with severe isolated GHD to identify potential underlying causes.
Abstract

Keywords:
auxological findingschildrenclinical characteristicsgrowth hormone deficiencymrineuroradiological assessment

More Related Videos

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies06:53

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies

Published on: July 4, 2017

11.1K
Tricolor Transgenic Murine Model for Studying Growth Plate Injury07:58

Tricolor Transgenic Murine Model for Studying Growth Plate Injury

Published on: September 6, 2024

607

Related Concept Videos

Nature and Nurture01:10

Nature and Nurture

Many human characteristics, like height, are shaped by both nature—in other words, by our genes—and by nurture, or our environment. For example, chronic stress during childhood inhibits the production of growth hormones and consequently reduces bone growth and height. Scientists estimate that 70-90% of variation in height is due to genetic differences among individuals, and 10-30% of variation in height is due to differences in the environments that individuals experience,...
20.5K
Signs of Puberty01:27

Signs of Puberty

Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
350
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.5K
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
158
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Overview of Protein Metabolism01:21

Overview of Protein Metabolism

Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
1.2K