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Higher remnant cholesterol is associated with an increased risk of amnestic mild cognitive impairment: a

Yating Ai1,2,3, Chunyi Zhou1, Ming Wang4

  • 1School of Nursing, Hubei University of Chinese Medicine, Wuhan, China.

Frontiers in Aging Neuroscience
|February 27, 2024
PubMed
Abstract

Insights

Higher remnant cholesterol (RC) levels are linked to amnestic mild cognitive impairment (aMCI) in older adults. This study suggests RC may be an independent indicator for aMCI, especially affecting naming abilities.

Area of Science:

  • Neuroscience
  • Cardiovascular Research
  • Gerontology

Background:

  • Amnestic mild cognitive impairment (aMCI) is a common precursor to Alzheimer's disease.
  • Remnant cholesterol (RC) is an emerging, overlooked risk factor for cognitive decline.

Purpose of the Study:

  • To investigate the association between plasma remnant cholesterol (RC) levels and amnestic mild cognitive impairment (aMCI).

Main Methods:

  • A total of 1,007 community-dwelling elders were recruited and categorized into aMCI (n=401) and normal cognitive groups (n=606).
  • Data collected included demographic information, cognitive screening, physical examinations, and blood lipid profiles.
  • Statistical analyses included binary logistic regression, partial correlation, and ROC curve analysis.

Main Results:

  • Individuals with aMCI exhibited significantly higher plasma RC levels compared to the normal cognitive group (p < 0.05).
  • RC levels were identified as an independent associated factor for aMCI (OR=1.477, p=0.014).
  • Higher RC levels correlated negatively with MoCA and Naming scores, and demonstrated independent predictive efficacy for aMCI (AUC=0.580, p < 0.001).

Conclusions:

  • Elevated plasma RC levels are an independent indicator for aMCI in older adults.
  • The association appears particularly relevant to the naming cognitive domain.
  • Further longitudinal research is warranted to confirm the predictive value of RC for aMCI.
Keywords:
Alzheimer’s diseaseamnestic mild cognitive impairmentcommunitycross-sectionalolder adultsremnant cholesterol

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