Role of PD-1 and immune cells in HSV infection and latency

A large proportion of the world's population is infected with HSV-1. Antiviral CD8⁺ T cells and CD8α⁺ dendritic cells are closely related to HSV-1 infection and latency. Latency-associated transcript of HSV-1 and PD-1 are involved in the regulation of latency and reactivation of HSV-1. Here, the role of latency-associated transcript, PD-1, CD8⁺ T cells and CD8α⁺ dendritic cells in HSV-1 infection, the inter-relationships between them and how these interactions lead to latency are discussed, possibly providing new ideas for the treatment of HSV-1 infection.