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Effect of ivermectin on murine mites
Journal of the American Veterinary Medical Association
|December 1, 1985
Summary
Two subcutaneous injections of ivermectin effectively eliminated mites in lab mice. A single dose offered only temporary mite reduction, highlighting the importance of a two-dose regimen for sustained parasite control.
Area of Science:
- Veterinary Parasitology
- Laboratory Animal Science
Background:
- Mite infestations (Myocoptes musculinus, Myobia musculi) are common in laboratory mice.
- Effective and safe treatments are crucial for maintaining animal welfare and research integrity.
Purpose of the Study:
- To evaluate the efficacy and safety of ivermectin for treating mite infestations in laboratory mice.
- To determine the optimal dosing regimen for complete mite elimination.
Main Methods:
- Laboratory mice with naturally occurring mite infestations were used.
- Two subcutaneous injections of ivermectin at 200 micrograms/kg, one week apart, were administered.
- Control groups received single injections of 200 or 100 micrograms/kg.
Main Results:
- The two-injection regimen of ivermectin (200 micrograms/kg) completely eliminated both Myocoptes musculinus and Myobia musculi infestations.
- Single injections of ivermectin (200 or 100 micrograms/kg) resulted in only temporary reductions in mite populations.
Conclusions:
- A two-dose subcutaneous administration of ivermectin at 200 micrograms/kg is a safe and effective treatment for common mite infestations in laboratory mice.
- This regimen provides a reliable method for parasite control in research animal populations.