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Updated: Jul 2, 2025

Studies of Chaperone-Cochaperone Interactions using Homogenous Bead-Based Assay
Published on: July 21, 2021
The HSP90 chaperone code regulates the crosstalk between proteostasis and autophagy
Sarah J Backe1,2, Jennifer A Heritz1,2,3, Mehdi Mollapour1,2,3
1Department of Urology, SUNY Upstate Medical University, Syracuse, NY, USA.
Abstract:
Proteostasis, the maintenance of proper protein folding, stability, and degradation within cells, is fundamental for cellular function. Two key players in this intricate cellular process are macroautophagy/autophagy and chaperoning of nascent proteins. Here, we explore the crosstalk between autophagy and the HSP90 chaperone in maintaining proteostasis, highlighting their interplay and significance in cellular homeostasis.Abbreviation: HSP90: heat shock protein 90; PTMs: post-translational modifications.
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