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Management of postinfectious inflammatory arthritis
Hailey Baker1, J Kennedy Amaral2, Robert T Schoen1
1Section of Rheumatology, Allergy, and Immunology, Yale School of Medicine.
Current Opinion in Rheumatology
|February 27, 2024
Summary
Postinfectious inflammatory arthritis, triggered by various pathogens, can range from mild to severe chronic conditions. Management strategies are evolving, with new disease-modifying treatments offering expanded options for patients.
Area of Science:
- Rheumatology
- Infectious Diseases
- Immunology
Background:
- Postinfectious inflammatory arthritis arises from diverse pathogens (bacteria, viruses, fungi, parasites).
- While acute infection treatment is crucial, some cases develop chronic arthritis.
- The condition presents a spectrum from self-limited arthralgia to severe, refractory arthritis requiring long-term management.
Approach:
- This review examines the broad spectrum of postinfectious inflammatory arthritis.
- It synthesizes conventional therapies and recent advancements in management.
- The article adopts the term 'postinfectious inflammatory arthritis' for a more inclusive disease definition.
Key Points:
- Ongoing research investigates antimicrobial therapy's role beyond acute infection to mitigate postinfectious inflammatory arthritis severity.
- Most cases are self-limited post-infection, managed symptomatically.
- A subset of patients develops chronic, challenging-to-manage postinfectious inflammatory arthritis.
Conclusions:
- The availability of biologic and targeted synthetic disease-modifying antirheumatic drugs (DMARDs) has broadened treatment options.
- Effective management requires understanding the diverse clinical presentations and pathogenic mechanisms.
- This review provides insights into current and emerging therapeutic strategies for postinfectious inflammatory arthritis.
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