Elevated plasma triglycerides increase the risk of psoriasis: a cohort and Mendelian randomization study
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View abstract on PubMed
Summary
This summary is machine-generated.Elevated plasma triglycerides, linked to inflammation, are causally associated with an increased risk of developing psoriasis. This finding holds true in both observational and genetic studies, confirming a significant link.
Area Of Science
- Cardiovascular Research
- Dermatology
- Genetics
Background
- Triglyceride-rich lipoproteins are known to be proinflammatory, contributing to low-grade systemic inflammation.
- The causal relationship between elevated plasma triglycerides and the development of psoriasis, a chronic inflammatory skin condition, remains unclear.
Purpose Of The Study
- To investigate the association between elevated plasma triglycerides and the risk of developing psoriasis.
- To determine if this association is causal using observational and Mendelian randomization analyses.
Main Methods
- Utilized data from the Copenhagen General Population Study (n=108,043) for plasma triglycerides and a triglyceride allele score (n=92,579).
- Replicated genetic findings in the UK Biobank (n=337,159).
- Defined psoriasis using International Classification of Diseases, version 10 (ICD-10) codes and topical antipsoriatic prescriptions.
Main Results
- An increased risk of psoriasis was observed with elevated plasma triglycerides in observational analysis (HR 1.26 per doubling).
- Mendelian randomization analysis indicated a causal odds ratio of 2.10 for incident psoriasis.
- Causality was confirmed by UK Biobank data, with similar results observed for mild psoriasis cases.
Conclusions
- Elevated plasma triglycerides are significantly associated with an increased risk of psoriasis.
- The study provides evidence for a causal link between high plasma triglycerides and psoriasis development.
- Findings were consistent across different analytical approaches and populations.
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