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Expression patterns of Piezo1 in the developing mouse forebrain.

Hye Yoon Kim1,2, Bokeum Kang1, Pa Reum Lee1

  • 1Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea.

Brain Structure & Function
|February 27, 2024
PubMed
Summary
This summary is machine-generated.

The Piezo1 channel, crucial for sensing mechanical cues in brain development, is expressed in developing mouse brains. Its activation influences neural cell migration, offering insights into mechanobiology and neurodevelopmental disorders.

Keywords:
Brain developmentEmbryogenesisMechanical cuesMigrationNeurogenesisPiezo1

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Mechanobiology

Background:

  • Cortical development malformations disrupt neural circuits, linked to psychiatric disorders.
  • Mechanical cues like shear stress and stiffness regulate neurogenesis.
  • Piezo1 channels transduce mechanical signals in embryogenesis.

Purpose of the Study:

  • Characterize cell-type-specific expression of Piezo1 during mouse cortical development.
  • Investigate the functional role of Piezo1 in embryonic neural cell behavior.

Main Methods:

  • RNAscope experiments on embryonic mouse forebrain sections (E12.5-E18.5).
  • Calcium imaging in embryonic brain slices using Piezo1 agonist Yoda1.
  • In vitro migration assays with pharmacological Piezo1 modulation.

Main Results:

  • Piezo1 transcripts localized to specific cell types during cortical development.
  • Yoda1 induced calcium influx in embryonic piriform cortices.
  • Piezo1 activation/inhibition altered neurosphere cell migration in vitro.

Conclusions:

  • Piezo1 expression is dynamically regulated during cortical development.
  • Piezo1 signaling influences neural cell migration.
  • Findings advance understanding of mechanotransduction in brain development.