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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
COVID-19 Vaccination Reactions and Risk of Breakthrough Infections Among People With Diabetes: Cohort Study Derived
Nancy A Dreyer1, Kendall B Knuth2, Yiqiong Xie2
1Dreyer Strategies LLC, Newton, MA, United States.
People with diabetes reported fewer COVID-19 vaccine side effects than those without diabetes. Breakthrough infection risk remained similar between groups, indicating comparable vaccine effectiveness.
Area of Science:
- Immunology
- Public Health
- Endocrinology
Background:
- Exploratory study comparing self-reported COVID-19 vaccine side effects and breakthrough infections.
- Focus on individuals with and without diabetes.
- Utilizes person-reported data for analysis.
Purpose of the Study:
- Evaluate differences in perceived COVID-19 vaccine side effects.
- Compare adults with diabetes versus those without.
- Analyze vaccine side effect perception using self-reported data.
Main Methods:
- Retrospective cohort study using online data (March 2021-July 2022).
- Participants (aged 18+) reported demographics, vaccination, side effects, and infections.
- Multivariate logistic regression adjusted for multiple covariates; pharmacy claims validated medication use.
Main Results:
- Individuals with diabetes (n=724) reported fewer side effects (mean 2.7) than those without (n=6417; mean 3.1).
- Lower adjusted risk for specific side effects (fatigue, headache) in people with diabetes.
- No significant difference in breakthrough COVID-19 infections observed between groups.
Conclusions:
- Diabetes status was associated with fewer self-reported vaccine side effects.
- COVID-19 vaccine effectiveness, indicated by breakthrough infection rates, was similar for both groups.
- Diabetes medication use did not consistently alter side effect risk.
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