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Testosterone Replacement Therapy in Orthopaedic Surgery.

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Testosterone replacement therapy (TRT) offers benefits but carries risks for orthopaedic health. This review examines TRT

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Area of Science:

  • Orthopaedic Surgery and Endocrinology
  • Investigating the intersection of hormonal therapy and musculoskeletal health.

Background:

  • Testosterone replacement therapy (TRT) is increasingly used for hypogonadism, gender affirmation, and other conditions.
  • Growing awareness and aging population drive TRT utilization, necessitating a review of its orthopaedic implications.
  • Potential risks include cardiovascular events and prostate issues, prompting investigation into orthopaedic effects.

Approach:

  • Comprehensive literature review on testosterone replacement therapy (TRT) and orthopaedic conditions.
  • Analysis of TRT's impact on osteoarthritis, joint arthroplasty, and musculotendinous pathology.
  • Evaluation of TRT's role in postoperative outcomes, including infection risk, healing, and bone-implant integration.

Key Points:

  • TRT's relationship with osteoarthritis development and total joint arthroplasty incidence is under investigation.
  • Musculotendinous pathology and postoperative infection risk are areas of concern with TRT.
  • TRT may enhance osseous healing, improve postoperative rehabilitation, and increase bone-implant integration.

Conclusions:

  • TRT presents a complex profile of potential benefits and risks within orthopaedic surgery.
  • Further research is needed to guide clinicians in optimizing TRT benefits while mitigating adverse orthopaedic outcomes.
  • Future studies should focus on risk stratification and personalized management strategies for patients on TRT undergoing orthopaedic procedures.