Related Experiment Video
Updated: May 5, 2026
07:32
Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
Published on: August 28, 2015
11.3K
Multifunctional Deep Eutectic Solvent-Based Microemulsion for Transdermal Delivery of Artemisinin.
Menghan Li1, Jing Yuan2, Zhuoni Liu1
1School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China.
Langmuir : the ACS Journal of Surfaces and Colloids
|February 27, 2024
Summary
This study developed a novel microemulsion using a deep eutectic solvent (DES) to enhance artemisinin delivery for malaria treatment. The formulation significantly improved artemisinin solubility and skin permeability.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Medicinal Chemistry
Background:
- Malaria remains a significant global health challenge, necessitating improved therapeutic strategies.
- Artemisinin, a key antimalarial drug derived from traditional Chinese medicine, faces limitations due to poor solubility, bioavailability, and short half-life.
- Advanced drug delivery systems are crucial to overcome artemisinin's pharmacokinetic challenges.
Purpose of the Study:
- To develop a novel delivery system for artemisinin using a multifunctional deep eutectic solvent (DES).
- To enhance the solubility and transdermal permeability of artemisinin.
- To explore the potential of a microemulsion formulation for improved artemisinin delivery.
Main Methods:
- A multifunctional DES was synthesized using ibuprofen and menthol.
- The DES was used to prepare an oil-in-water (O/W) microemulsion with Tween-80 and Span-20 surfactants.
- Artemisinin solubility and in vitro permeability were evaluated using the developed microemulsion.
Main Results:
- The DES formulation increased artemisinin solubility by up to 400-fold.
- The O/W microemulsion significantly enhanced artemisinin skin permeability, attributed to menthol and microemulsion structure.
- Co-permeation of artemisinin and ibuprofen suggested potential synergistic therapeutic effects.
Conclusions:
- A microemulsion based on a multifunctional DES offers an effective strategy for artemisinin transdermal delivery.
- This formulation addresses key limitations of artemisinin, improving its therapeutic potential.
- The developed system shows promise for advancing antimalarial drug delivery.
Related Concept Videos
01:27Bioavailability Enhancement: Drug Permeability Enhancement
358
After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
358
01:18Transdermal Drug Delivery Systems
238
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
238